Metaverse attracted worldwide attention since 2022. The Metaverse is considered the third wave of the Internet revolution, able to support persistent interconnected online 3D virtual environments (3DVE), and promising to bring new levels of social connection and collaboration. How to effectively design and use Metaverse in teaching and learning remains crucial for the development of effective learning experiences.Meanwhile, Generative Al such as ChatGPT entered the spotlight in 2023 and stirred conversations around the world on its usage and “threats”to education and training. How to effectively use Generative Al in various disciplines remains a popular research topic. In this presentation, Prof. Wang will first showcase exemplary Metaverse technologies and platforms, then share a new 3D Edu-Metaverse Ecosystem she created with her students. She will then discuss how to integrate Metaverse with AIGC in learning settings. Her presentation will zoom in on the use of Al-enabled tools and platforms for entrepreneurship education across North America and Asia. In addition, she will also explore the ethical considerations of using Al in different educational settings.