This special issue in IEEE-TLT (Transactions on Learning Technologies) will invite research on the intersection of entrepreneurship education, lifelong learning, and artificial intelligence with the goal of examining how the emergence of AI technologies will promote change in these fields. In particular, this special issue aims to address the critical challenges and opportunities that arise from the implementation of entrepreneurship education and lifelong learning in various learning settings. By collecting articles related to these topics, the special issue will present a unique opportunity to explore the intersection of AI empowered entrepreneurship education and lifelong learning. It will provide a much – needed platform for authors to submit original research on the latest reviews, theoretical frameworks, and empirical findings on the application of AI in these two fields.